Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038579 | 0.84 | AKR1B1 (0.56) | ALDH1A1POLBAKR1B1TSHRTDP1 | |
| SCHEMBL9040587 | 0.79 | AKR1B1 (0.61) | ALDH1A1POLBAKR1B1LMNATSHR | |
| SCHEMBL9037891 | 0.75 | TSHR (0.59) | ALDH1A1POLBAKR1B1TSHRTDP1 | |
| SCHEMBL9038575 | 0.75 | MEN1 (0.42) | ALDH1A1POLBTNKSTNKS2AKR1B1 | |
| SCHEMBL11637692 | 0.74 | PDE7A (0.54) | ALDH1A1POLBTNKSTNKS2LMNA | |
| SCHEMBL30930016 | 0.73 | PDE7A (0.57) | ALDH1A1POLBTNKSTNKS2LMNA | |
| SCHEMBL11641417 | 0.73 | PDE7A (0.57) | ALDH1A1POLBTNKSTNKS2LMNA | |
| SCHEMBL30671022 | 0.72 | ALDH1A1 (0.41) | ALDH1A1POLBAKR1B1GRIN1GRIN2A | |
| SCHEMBL28498656 | 0.70 | GRIN1 (0.45) | ALDH1A1GRIN1GRIN2ASLC6A4GRIN2D | |
| SCHEMBL8728316 | 0.70 | ALDH1A1 (0.45) | ALDH1A1POLBAKR1B1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6664258-B1 | Transphenylpiperazines; central dopaminergic activity | PFIZER INC | 2003-12-16 | — | — | US | disclosed |