Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9040587 | 0.80 | AKR1B1 (0.61) | ALDH1A1LMNATDP1AKR1B1POLB | |
| SCHEMBL9038579 | 0.75 | AKR1B1 (0.56) | ALDH1A1TDP1AKR1B1POLB | |
| SCHEMBL7254124 | 0.75 | ALDH1A1 (0.43) | ALDH1A1LMNATDP1AKR1B1POLB | |
| SCHEMBL9234892 | 0.74 | AKR1B1 (0.57) | MEN1KMT2ATDP1AKR1B1 | |
| SCHEMBL9037891 | 0.73 | TSHR (0.59) | ALDH1A1TDP1AKR1B1POLB | |
| SCHEMBL9042847 | 0.71 | AKR1B1 (0.41) | MEN1KMT2AAKR1B1 | |
| SCHEMBL15606172 | 0.71 | AKR1B1 (0.41) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL9039898 | 0.70 | AVPR1A (0.39) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL9041593 | 0.68 | PARP1 (0.44) | MEN1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL30671022 | 0.67 | ALDH1A1 (0.41) | ALDH1A1TDP1AKR1B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5098925-A | Neurological disorders in mammals | ICI AMERICAS INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0441598-A2 | Spiroisoindole compounds | ZENECA INC. (US) | 1991-08-14 | — | — | EP | disclosed |