Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.42 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327299 | 0.96 | HTR4 (0.54) | HTR4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL7257582 | 0.89 | HTR4 (0.61) | HTR4CCR2DRD2DRD4DRD3 | |
| SCHEMBL7259058 | 0.88 | KCNH2 (0.56) | HTR4CCR2DRD2DRD4DRD3 | |
| SCHEMBL6336300 | 0.86 | CCR2 (0.59) | HTR4CCR2GSK3BCHRM4DRD2 | |
| SCHEMBL7257655 | 0.85 | CCR2 (0.49) | HTR4CCR2GSK3BCHRM4DRD2 | |
| SCHEMBL7254822 | 0.85 | HTR4 (0.49) | HTR4CCR2CHRM4DRD2DRD4 | |
| SCHEMBL6329186 | 0.84 | HTR4 (0.66) | HTR4CCR2DRD2DRD4DRD3 | |
| SCHEMBL6329068 | 0.84 | HTR4 (0.56) | HTR4CCR2DRD2DRD4DRD3 | |
| SCHEMBL7257704 | 0.84 | HTR4 (0.54) | HTR4CCR2DRD2DRD4DRD3 | |
| SCHEMBL6331358 | 0.83 | HTR4 (0.58) | HTR4CHRM4DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |