Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335672 | 0.96 | HTR4 (0.52) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL7259058 | 0.89 | KCNH2 (0.56) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL7257582 | 0.89 | HTR4 (0.61) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL6329182 | 0.87 | HTR4 (0.47) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL6329068 | 0.86 | HTR4 (0.56) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL7254158 | 0.85 | HTR4 (0.51) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL6329186 | 0.84 | HTR4 (0.66) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL6329791 | 0.84 | KCNH2 (0.61) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL6336876 | 0.84 | HTR4 (0.54) | HTR4KCNH2CACNA1IDRD2DRD4 | |
| SCHEMBL6329269 | 0.84 | DRD2 (0.58) | HTR4DRD2DRD4DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |