Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 6/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326657 | 0.95 | HTR4 (0.49) | HTR4CXCR4DRD2DRD4DRD3 | |
| SCHEMBL6336897 | 0.87 | HTR4 (0.50) | HTR4DRD2DRD4DRD3ACHE | |
| SCHEMBL6329577 | 0.85 | TP53 (0.54) | HTR4CXCR4DRD2DRD4DRD3 | |
| SCHEMBL6329269 | 0.85 | DRD2 (0.58) | HTR4DRD2DRD4DRD3ACHE | |
| SCHEMBL6329068 | 0.85 | HTR4 (0.56) | HTR4DRD2DRD4DRD3ACHE | |
| SCHEMBL6335662 | 0.84 | HTR4 (0.50) | HTR4DRD2DRD4DRD3ACHE | |
| SCHEMBL6328740 | 0.84 | HDAC3 (0.50) | HTR4DRD2DRD4DRD3ACHE | |
| SCHEMBL7259046 | 0.84 | HTT (0.49) | HTR4CXCR4DRD2DRD4DRD3 | |
| SCHEMBL6329054 | 0.84 | TP53 (0.57) | HTR4CXCR4DRD2DRD4DRD3 | |
| SCHEMBL7259558 | 0.83 | HTR4 (0.46) | HTR4CXCR4DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |