Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 4/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL618431 | 0.68 | — | — | |
| SCHEMBL8616571 | 0.66 | KMT2A (0.50) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL6152260 | 0.65 | ALDH1A1 (0.33) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL19183362 | 0.64 | — | — | |
| SCHEMBL23413226 | 0.64 | GSK3B (0.36) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL14351455 | 0.64 | LMNA (0.50) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL4613286 | 0.64 | ALDH1A1 (0.33) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL4612505 | 0.64 | ALDH1A1 (0.41) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL12230949 | 0.64 | — | — | |
| SCHEMBL185620 | 0.64 | LMNA (0.35) | KMT2AMAPTALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721015-B1 | PROCESS FOR 4-METHYLOXAZOLE-5-CARBOXAMIDE | DSM IP ASSETS BV (NL) | 2017-03-01 | — | — | EP | claimed |
| WO-2003053959-A1 | HETEROCYCLYLAMINO CARBONYLURACILS | BAYER HEALTHCARE AG (DE) | 2003-07-03 | — | — | WO | disclosed |
| EP-0037471-A1 | 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |