SCHEMBL7254688

SCHEMBL7254688

O=C(O)c1n[nH]c(C(=O)O)c1O

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 1/20 0.48
HCAR2 Q8TDS4 16/20 0.42
KMT2A Q03164 1/20 0.39
TSHR P16473 1/20 0.38
SLC6A4 P31645 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3152179 0.76 HCAR2 (0.42) KDM4CHCAR2KMT2ATSHRSLC6A4
SCHEMBL30107036 0.74 HCAR2 (0.42) KDM4CHCAR2KMT2ATSHR
SCHEMBL26963252 0.74 HCAR2 (0.41) KDM4CHCAR2KMT2ATSHRSLC6A4
SCHEMBL8807725 0.67 HCAR2 (0.39) HCAR2KMT2ATSHR
SCHEMBL8842823 0.67 RAB9A (0.50) KMT2A
SCHEMBL29956356 0.67 HCAR2 (0.53) KDM4CHCAR2KMT2ATSHR
SCHEMBL28543309 0.66 HCAR2 (0.45) KDM4CHCAR2
SCHEMBL18660404 0.66 KDM4C (1.00) KDM4CKMT2ATSHR
SCHEMBL1816267 0.66 HCAR2 (0.50) KDM4CHCAR2KMT2ATSHR
SCHEMBL7234538 0.65 HCAR2 (0.57) HCAR2KMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119505204-A Multifunctional flame-retardant anti-dripping copolyester and preparation method and application thereof 四川大学 2025-02-25 CN disclosed
US-6617347-B1 Substituted pyrazoles are treatment of Type II diabetes and obesity. ELI LILLY AND COMPANY 2003-09-09 US disclosed
EP-1036064-A4 SELECTIVE BETA 3-ADRENERGIC AGONISTS LILLY CO ELI (US) 2002-11-27 EP disclosed
US-6232337-B1 USEFUL IN THE TREATMENT OF TYPE II DIABETES AND OBESITY ELI LILLY AND COMPANY 2001-05-15 US disclosed
EP-1036064-A1 SELECTIVE BETA 3-ADRENERGIC AGONISTS ELI LILLY AND COMPANY (US) 2000-09-20 EP disclosed
US-6046227-A USEFUL IN THE TREATMENT OF TYPE II DIABETES AND OBESITY; A SUBSTITUTED PYRAZINE COMPOUND ELI LILLY AND COMPANY (US) 2000-04-04 US disclosed
WO-1999029672-A1 SELECTIVE β3 ADRENERGIC AGONISTS ELI LILLY AND COMPANY (US) 1999-06-17 WO disclosed
EP-0921120-A1 Selective beta 3 adrenergic agonists ELI LILLY AND COMPANY (US) 1999-06-09 EP disclosed