Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254370 | 0.90 | F2 (0.43) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7254368 | 0.90 | F2 (0.43) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7255193 | 0.80 | F2 (0.39) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7259758 | 0.76 | F2 (0.36) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7254244 | 0.71 | MEN1 (0.41) | F2CYP2C9 | |
| SCHEMBL7254246 | 0.71 | MEN1 (0.41) | F2CYP2C9 | |
| SCHEMBL7255189 | 0.68 | MDM2 (0.33) | F2MASP2CYP2C9PTGER1 | |
| SCHEMBL5855156 | 0.68 | MEN1 (0.47) | F2PRSS1PRSS2PRSS3CYP2C9 | |
| SCHEMBL7260066 | 0.68 | F2 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5855369 | 0.67 | MEN1 (0.46) | F2PRSS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003011222-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | disclosed |