SCHEMBL7255208

SCHEMBL7255208

CC(Cl)(C(=O)Cl)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.52
MAPT P10636 1/20 0.48
KMT2A Q03164 1/20 0.48
CYP2C19 P33261 1/20 0.47
HIF1A Q16665 1/20 0.47
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HDAC9 Q9UKV0 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
TSHR P16473 1/20 0.44
KCNN4 O15554 1/20 0.42
ALDH1A1 P00352 2/20 0.41
ALOX15 P16050 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29613223 0.84 CYP1A2 (0.60) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL11715049 0.84 CYP1A2 (0.54) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL305060 0.84 CYP1A2 (0.60) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL16753453 0.84 CYP1A2 (0.60) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL1817185 0.80 MAPT (0.63) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL5552907 0.80 CYP1A2 (0.50) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL8860523 0.79 MAPT (0.50) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL3674752 0.79 HDAC3 (0.57) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL5552910 0.79 TSHR (0.46) CYP1A2MAPTKMT2ACYP2C19HIF1A
SCHEMBL343135 0.79 MAPT (0.61) CYP1A2MAPTKMT2ACYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003035636-A2 PROCESS FOR THE PREPARATION OF 3 - ISOCHROMANONE SYNGENTA LIMITED (GB) 2003-05-01 WO disclosed
EP-0532528-A1 DERIVATIVES OF HYDROXY AND ALKOXY PYRIDINES PFIZER INC. (US) 1993-03-24 EP disclosed
WO-1991018881-A1 DERIVATIVES OF HYDROXY AND ALKOXY PYRIDINES PFIZER INC. (US) 1991-12-12 WO disclosed