Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255711 | 1.00 | ALPL (0.38) | ALPLMAOBMAPTKDM4EHTT | |
| SCHEMBL7256504 | 0.75 | JAK2 (0.51) | ALPLMAOBMAPTKDM4EMEN1 | |
| SCHEMBL7259137 | 0.71 | CYP1A2 (0.50) | ALPLKMT2AHPGDMAPK1ALDH1A1 | |
| SCHEMBL7126825 | 0.69 | GSK3B (0.48) | CLK4GSK3AFAAH | |
| SCHEMBL7126823 | 0.69 | GSK3B (0.48) | CLK4GSK3AFAAH | |
| SCHEMBL2491365 | 0.64 | HPGD (0.36) | MAPTHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3462734 | 0.64 | HPGD (0.36) | MAPTHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29768210 | 0.64 | GAA (0.37) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26675427 | 0.64 | GAA (0.37) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10946287 | 0.60 | CNR2 (0.56) | ALPLMAOBKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |