Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 2/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388772 | 0.78 | DYRK1A (0.59) | PLK3CDK2MAPK1FLT4MAPK8 | |
| SCHEMBL1460319 | 0.78 | GSK3A (0.59) | JAK2KMT2AMAPK1MAPK8LIMK1 | |
| SCHEMBL7259137 | 0.77 | CYP1A2 (0.50) | ALPLHPGDALOX15KMT2ACDK2 | |
| SCHEMBL7255711 | 0.75 | ALPL (0.38) | JAK2JAK1TYK2JAK3MAOB | |
| SCHEMBL7255702 | 0.75 | ALPL (0.38) | JAK2JAK1TYK2JAK3MAOB | |
| Hydrazine SCHEMBL7155128 | 0.75 | GSK3A (0.56) | JAK2KMT2AMAPK1MAPK8LIMK1 | |
| SCHEMBL13329263 | 0.71 | HSP90AA1 (0.46) | JAK2JAK1TYK2JAK3HSP90AA1 | |
| SCHEMBL13329694 | 0.71 | JAK2 (0.47) | JAK2JAK1TYK2JAK3HSP90AA1 | |
| SCHEMBL16517285 | 0.71 | TDP1 (0.40) | JAK2JAK1TYK2JAK3CHEK1 | |
| SCHEMBL3499089 | 0.70 | ALPL (0.57) | JAK2JAK1TYK2JAK3HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |