Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.48 |
| ▸ | GSK3A | P49840 | 6/20 | 0.48 |
| ▸ | AXL | P30530 | 7/20 | 0.43 |
| ▸ | CDK8 | P49336 | 5/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126825 | 1.00 | GSK3B (0.48) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL29930893 | 0.75 | GSK3B (0.58) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL5387619 | 0.73 | GSK3B (0.59) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL7168419 | 0.72 | GSK3B (0.56) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL7255702 | 0.69 | ALPL (0.38) | GSK3ACLK4FAAH | |
| SCHEMBL7255711 | 0.69 | ALPL (0.38) | GSK3ACLK4FAAH | |
| SCHEMBL29930698 | 0.68 | DYRK1A (0.60) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL18137820 | 0.67 | AXL (0.61) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL7132408 | 0.67 | GSK3B (0.60) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL7135501 | 0.67 | GSK3B (0.64) | GSK3BGSK3AAXLCDK8TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003045949-A1 | PYRAZOLOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |