Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | STS | P08842 | 3/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9483327 | 0.88 | PDE3B (0.68) | PDE3BPDE3AMEN1KMT2ANPC1 | |
| SCHEMBL7257829 | 0.82 | ESR1 (0.46) | PDE3BPDE3AMEN1KMT2APARP1 | |
| SCHEMBL5727283 | 0.82 | ESR1 (0.52) | PDE3BPDE3AMEN1KMT2ANPC1 | |
| SCHEMBL5727262 | 0.80 | POLB (0.49) | PDE3BPDE3AMEN1KMT2ANPC1 | |
| SCHEMBL5726426 | 0.80 | PGR (0.61) | PDE3BPDE3AMEN1KMT2ANPC1 | |
| SCHEMBL9484835 | 0.79 | SMN1; SMN2 (0.67) | PDE3BPDE3ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL1848088 | 0.78 | PDE3B (1.00) | PDE3BPDE3AMEN1KMT2ANPC1 | |
| SCHEMBL4823687 | 0.78 | CES2 (0.77) | MEN1KMT2ANPC1RAB9ASTS | |
| SCHEMBL31414638 | 0.78 | CES2 (0.77) | MEN1KMT2ANPC1RAB9ASTS | |
| SCHEMBL9484422 | 0.77 | ALDH1A1 (0.50) | PDE3BPDE3AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003027108-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS HYPOGLYCAEMIC AND HYPOLIPIDEMIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2003-04-03 | — | — | WO | disclosed |