Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.58 |
| ▸ | GSK3B | P49841 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.46 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257484 | 0.83 | KDM4E (0.46) | GSK3AGSK3BMAPK1 | |
| SCHEMBL7256564 | 0.82 | GSK3A (0.58) | GSK3AGSK3BMAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL1555312 | 0.79 | IKBKB (0.48) | GSK3AGSK3BFGFR1FGFR2PDPK1 | |
| SCHEMBL10334229 | 0.72 | PDE3B (0.50) | GSK3AGSK3BRPS6KA3CDK2CYP3A4 | |
| SCHEMBL7261268 | 0.71 | GSK3A (0.54) | GSK3AGSK3BMAPK1FGFR1PDPK1 | |
| SCHEMBL13329422 | 0.70 | ALDH1A1 (0.40) | GSK3AGSK3BMAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL26675449 | 0.70 | JAK2 (0.44) | GSK3AGSK3BMAPK1MAP2K4FGFR1 | |
| SCHEMBL10333628 | 0.69 | ILK (0.42) | GSK3AGSK3BHSP90AB1CDK2 | |
| SCHEMBL1056975 | 0.69 | ALDH1A1 (0.49) | GSK3AGSK3BMAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL25366182 | 0.68 | GAA (0.58) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068773-A1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |