Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CD4 | P01730 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258342 | 0.90 | TSHR (0.39) | LMNAHTTTSHRCYP2D6USP2 | |
| SCHEMBL7258008 | 0.89 | TSHR (0.44) | LMNAHTTTSHRCYP2D6USP2 | |
| SCHEMBL6078359 | 0.86 | ALDH1A1 (0.42) | LMNATSHRCYP2D6USP2CYP3A4 | |
| SCHEMBL7262868 | 0.83 | MMP2 (0.34) | LMNAHTTTSHR | |
| SCHEMBL4516479 | 0.82 | ALDH1A1 (0.39) | LMNAHTTTSHRCYP2D6USP2 | |
| SCHEMBL7261956 | 0.82 | F10 (0.42) | LMNAHTTTSHRCYP2D6CYP3A4 | |
| SCHEMBL7262067 | 0.80 | LSS (0.36) | LMNAHTTTSHR | |
| SCHEMBL4528724 | 0.79 | F10 (0.44) | — | |
| SCHEMBL6079366 | 0.79 | F10 (0.49) | LMNATSHRCYP2D6USP2CYP3A4 | |
| SCHEMBL4520059 | 0.79 | CYP2D6 (0.45) | TSHRCYP2D6USP2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |