Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257489 | 0.90 | LMNA (0.43) | TSHRLMNAHTTCYP2D6CYP3A4 | |
| SCHEMBL7258008 | 0.88 | TSHR (0.44) | TSHRLMNAHTTCYP2D6CYP3A4 | |
| SCHEMBL6078643 | 0.87 | F10 (0.41) | TSHRLMNAHTTALDH1A1MEN1 | |
| SCHEMBL6079058 | 0.80 | MGLL (0.42) | TSHRCYP2D6CYP3A4USP2ALDH1A1 | |
| SCHEMBL6078359 | 0.78 | ALDH1A1 (0.42) | TSHRLMNACYP2D6CYP3A4USP2 | |
| SCHEMBL6854877 | 0.77 | ALDH1A1 (0.42) | TSHRLMNAHTTCYP2D6CYP3A4 | |
| SCHEMBL7261993 | 0.76 | TGM2 (0.42) | MEN1KMT2AMMP1MMP9 | |
| SCHEMBL6079034 | 0.76 | F10 (0.41) | TSHRLMNAHTTCYP2D6CYP3A4 | |
| SCHEMBL7261681 | 0.75 | TGM2 (0.45) | TSHRMEN1KMT2ACYP2C19SMN1; SMN2 | |
| SCHEMBL6079274 | 0.75 | F10 (0.47) | TSHRLMNACYP2D6USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |