Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995114 | 0.83 | TNFSF11 (0.61) | ALDH1A1HPGDKDM4EKMT2ANQO1 | |
| SCHEMBL297205 | 0.80 | CA1 (0.56) | ALDH1A1KMT2APOLBATM | |
| SCHEMBL14579661 | 0.80 | TNFSF11 (0.58) | ALDH1A1HPGDKDM4EKMT2ANQO1 | |
| SCHEMBL441442 | 0.79 | NQO1 (0.68) | ALDH1A1HPGDKDM4EKMT2ANQO1 | |
| SCHEMBL30459979 | 0.79 | NQO1 (0.68) | ALDH1A1HPGDKDM4EKMT2ANQO1 | |
| SCHEMBL6541925 | 0.79 | MAPT (0.41) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL30412939 | 0.78 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL978576 | 0.78 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL10962426 | 0.78 | CA12 (0.61) | ALDH1A1KMT2ANPC1POLBMEN1 | |
| SCHEMBL11042130 | 0.76 | KMT2A (0.39) | ALDH1A1HPGDKDM4EKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006443-A2 | 2- 4-(NAPHTALIN-2-YL)-THIAZOL-2-YLAMINOCARBONYL BENZOIC ACID AND 2- 4-(NAPHTALIN-2-YL)-PYRIMIDIN-2-YLAMINOCARBONYL BENZOIC ACID AND ADDITIONAL COMPOUNDS SERVING AS TELOMERASE INHIBITORS FOR USE IN TUMOR THERAPY | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-23 | — | — | WO | disclosed |