Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 known ✓ | P08912 | 6/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.47 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.43 |
| ▸ | CHRM4 known ✓ | P08173 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | GALR3 | O60755 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10300016 | 0.98 | THRB (0.53) | THRBTSHRCHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL8840606 | 0.93 | THRB (0.46) | THRBTSHRCHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL18428167 | 0.93 | TSHR (0.53) | THRBTSHRCHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL31388384 | 0.91 | THRB (0.44) | THRBTSHRCHRM5CHRM1CHRM3 | |
| SCHEMBL23530292 | 0.90 | TSHR (0.55) | THRBTSHRCHRM5CHRM1CHRM3 | |
| SCHEMBL14438897 | 0.90 | THRB (0.47) | THRBTSHRCHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL1011904 | 0.90 | THRB (0.47) | THRBTSHRCHRM5CHRM1CHRM3 | |
| SCHEMBL4790127 | 0.90 | THRB (0.47) | THRBTSHRCHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL4367449 | 0.90 | THRB (0.52) | THRBTSHRCHRM5CHRM1CHRM3 | |
| SCHEMBL23375334 | 0.90 | TSHR (0.55) | THRBTSHRCHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3639066-B1 | CELL GROWTH INHIBITING COPOLYMER FOR USE IN OPHTHALMIC IMPLANTS | SHIUEY YICHIEH (US) | 2025-10-29 | — | — | EP | claimed |
| US-12023405-B2 | Antimicrobial polymer for use in ophthalmic implants | KERAMED INC (US) | 2024-07-02 | — | — | US | claimed |
| EP-3850018-B1 | ANTIMICROBIAL CONTACT LENSES | KERAMED INC (US) | 2023-08-23 | — | — | EP | claimed |
| EP-3509593-B1 | ANTIMICROBIAL POLYMER FOR USE IN OPHTHALMIC IMPLANTS | KERAMED INC (US) | 2022-11-09 | — | — | EP | claimed |
| US-20210369607-A1 | Antimicrobial Contact Lenses | KeraMed, Inc. (US) | 2021-12-02 | — | — | US | claimed |
| US-11185609-B2 | Cell growth inhibiting copolymer for use in ophthalmic implants | KeraMed, Inc. (US) | 2021-11-30 | — | — | US | claimed |
| EP-3850018-A1 | ANTIMICROBIAL CONTACT LENSES | Keramed, Inc. (US) | 2021-07-21 | — | — | EP | claimed |
| US-20210077249-A1 | Antimicrobial Polymer for Use in Ophthalmic implants | KeraMed, Inc. (US) | 2021-03-18 | — | — | US | claimed |
| US-20200383907-A1 | Antimicrobial Polymer for Use in Ophthalmic implants | KeraMed, Inc. (US) | 2020-12-10 | — | — | US | claimed |
| EP-3745998-A1 | ANTIMICROBIAL POLYMER FOR USE IN OPHTHALMIC IMPLANTS | KeraMed, Inc. (US) | 2020-12-09 | — | — | EP | claimed |
| EP-3509593-A1 | ANTIMICROBIAL POLYMER FOR USE IN OPHTHALMIC IMPLANTS | Keramed, Inc. (US) | 2019-07-17 | — | — | EP | claimed |
| US-10307369-B2 | Antimicrobial polymer for use in ophthalmic implants | KeraMed, Inc. | 2019-06-04 | — | — | US | claimed |
| US-20180361018-A1 | CELL GROWTH INHIBITING COPOLYMER FOR USE IN OPHTHALMIC IMPLANTS | SHIUEY YICHIEH (US) | 2018-12-20 | — | — | US | claimed |
| WO-2018232025-A1 | CELL GROWTH INHIBITING COPOLYMER FOR USE IN OPHTHALMIC IMPLANTS | SHIUEY YICHIEH (US) | 2018-12-20 | — | — | WO | claimed |
| WO-2018048982-A1 | ANTIMICROBIAL POLYMER FOR USE IN OPHTHALMIC IMPLANTS | KeraMed, Inc. (US) | 2018-03-15 | — | — | WO | claimed |
| US-20180064643-A1 | Antimicrobial Polymer for Use in Ophthalmic implants | KeraMed, Inc. | 2018-03-08 | — | — | US | claimed |
| US-8889196-B2 | Dental composites comprising nanoparticles of amorphous calcium phosphate | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-11-18 | — | — | US | claimed |
| EP-2588140-A2 | DENTAL COMPOSITES COMPRISING NANOPARTICLES OF AMORPHOUS CALCIUM PHOSPHATE | University of Maryland, Baltimore (US) | 2013-05-08 | — | — | EP | claimed |
| US-20130108708-A1 | DENTAL COMPOSITES COMPRISING NANOPARTICLES OF AMORPHOUS CALCIUM PHOSPHATE | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-05-02 | — | — | US | claimed |
| WO-2012003290-A2 | DENTAL COMPOSITES COMPRISING NANOPARTICLES OF AMORPHOUS CALCIUM PHOSPHATE | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2012-01-05 | — | — | WO | claimed |