Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033152 | 0.83 | KDR (0.78) | KDRABCB1ABCC1ABCG2MAPK8 | |
| SCHEMBL7253189 | 0.77 | MAPT (0.44) | SYKSTK17AMEN1NPC1MAPT | |
| SCHEMBL7258541 | 0.76 | SYK (0.58) | KDRULK1ULK2MAPK8SYK | |
| SCHEMBL2791886 | 0.76 | ABCB1 (0.61) | ABCB1ABCC1ABCG2MAPK8PABPC1 | |
| SCHEMBL6210503 | 0.75 | PTK2 (0.54) | KDRULK1ULK2MAPK8SYK | |
| SCHEMBL5758552 | 0.75 | NPC1 (0.60) | ABCB1ABCC1ABCG2ULK1ULK2 | |
| SCHEMBL657592 | 0.74 | SYK (0.76) | MAPK8SYKAURKAAURKB | |
| SCHEMBL7258580 | 0.74 | SYK (0.52) | KDRULK1ULK2MAPK8SYK | |
| SCHEMBL1011248 | 0.74 | PABPC1 (0.59) | ABCB1ABCC1ABCG2MAPK8PABPC1 | |
| SCHEMBL4000667 | 0.73 | JAK3 (0.61) | KDRMAPK8SYKCDK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003030909-A1 | 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |