Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betaxolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | NPY2R | P49146 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betaxolol SCHEMBL29049065 | 0.92 | LMNA (0.84) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL26664793 | 0.87 | ADRB1 (0.90) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL26664844 | 0.87 | ADRB1 (0.90) | LMNAADRB1ADRB2GAABLM | |
| Levobetaxolol SCHEMBL42795 | 0.87 | LMNA (1.00) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL42794 | 0.87 | LMNA (1.00) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL26664797 | 0.86 | ADRB1 (0.88) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL23530 | 0.86 | ADRB1 (1.00) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL4997902 | 0.86 | ADRB1 (1.00) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL6512495 | 0.86 | ADRB1 (1.00) | LMNAADRB1ADRB2GAABLM | |
| Betaxolol SCHEMBL23531 | 0.86 | ADRB1 (1.00) | LMNAADRB1ADRB2GAABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645963-B2 | Incorporation of a C3-7 fatty acid, e.g., sorbic acid, improves the penetration of the beta-blocker, e.g., carteolol hydrochloride, into the eye and retention in the eye tissues; glaucoma; vision defects | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2003-11-11 | — | — | US | disclosed |
| US-20010041721-A1 | Prolonged-action eye drop | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2001-11-15 | — | — | US | disclosed |
| US-20010012859-A1 | Prolonged-action eye drop | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2001-08-09 | — | — | US | disclosed |