Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22116197 | 0.90 | HTR1A (0.48) | SCN4AKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL30308968 | 0.90 | HTR1A (0.48) | SCN4AKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL20611234 | 0.87 | SCN4A (0.50) | SCN4AKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3032643 | 0.82 | ALDH1A1 (0.54) | KMT2AMEN1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL21325165 | 0.81 | KMT2A (0.45) | SCN4AKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11121575 | 0.81 | KMT2A (0.61) | KMT2AMEN1SMN1; SMN2MAPTTP53 | |
| SCHEMBL21325170 | 0.80 | SCN4A (0.74) | SCN4AL3MBTL1 | |
| SCHEMBL30271483 | 0.80 | HPGD (0.55) | SCN4AKMT2ASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL27008284 | 0.80 | HPGD (0.55) | SCN4AKMT2ASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL767590 | 0.79 | ALOX15 (0.62) | KMT2AMEN1SMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6646012-B2 | Central nervous system analgesic; hypotensive agents; antiarrhythmia agents; antidiabetic agents | THERAVANCE, INC. | 2003-11-11 | — | — | US | claimed |