Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ADA | P00813 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 4/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258788 | 0.89 | CHEK2 (0.39) | CHEK2CHEK1MKNK2SCN9AADA | |
| SCHEMBL7258881 | 0.81 | ADA (0.39) | CHEK2MKNK2SCN9AJAK2ADA | |
| SCHEMBL7258747 | 0.81 | ADA (0.39) | CHEK2CHEK1MKNK2HSD17B1HSD17B2 | |
| SCHEMBL7263018 | 0.79 | ADA (0.41) | CHEK2MKNK2HSD17B1HSD17B2JAK2 | |
| SCHEMBL7259458 | 0.78 | ADA (0.40) | CHEK2CHEK1MKNK2SCN9AADA | |
| SCHEMBL5671212 | 0.78 | ADA (0.63) | CHEK2CHEK1MKNK1MKNK2HSD17B1 | |
| SCHEMBL7259601 | 0.77 | ADA (0.44) | ADA | |
| SCHEMBL7264341 | 0.77 | CHEK2 (0.35) | CHEK2CHEK1MKNK2SCN9AADA | |
| SCHEMBL7264346 | 0.76 | ATP4A (0.38) | ADA | |
| SCHEMBL7258942 | 0.76 | ADA (0.43) | CHEK2ADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006437-A1 | IMIDAZOLE DERIVATIVES AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-23 | — | — | WO | claimed |
| WO-2003006437-A1 | IMIDAZOLE DERIVATIVES AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-23 | — | — | WO | disclosed |