Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 4/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21848527 | 0.76 | KHK (0.45) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL454902 | 0.76 | MAOB (0.64) | HRH3MAOBKDM4EALDH1A1HPGD | |
| SCHEMBL30694751 | 0.75 | XDH (0.61) | PYGLPYGMHRH3MMP2MMP13 | |
| SCHEMBL3240597 | 0.72 | HRH3 (0.59) | PYGLPYGMHRH3MMP2MMP13 | |
| SCHEMBL13386801 | 0.71 | MMP2 (0.60) | PYGLPYGMHRH3MMP2MMP13 | |
| SCHEMBL15571271 | 0.70 | POLB (0.55) | ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL15683130 | 0.68 | CREBBP (0.50) | HRH3MMP2MMP13XDHMEN1 | |
| SCHEMBL30047012 | 0.68 | HRH3 (0.51) | PYGLPYGMHRH3MMP2MMP13 | |
| SCHEMBL3246114 | 0.68 | HRH3 (0.51) | PYGLPYGMHRH3MMP2MMP13 | |
| SCHEMBL19720917 | 0.68 | TLR9 (0.45) | PYGLPYGMMAPKAPK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051871-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AND THEIR USE AS ORXIN RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |