Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 5/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160138 | 0.78 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3LMNAOPRD1 | |
| Hydrochloric Acid SCHEMBL22797859 | 0.77 | SLC6A2 (0.53) | SLC6A4SLC6A2SLC6A3LMNAOPRD1 | |
| SCHEMBL2995935 | 0.76 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3TACR1KCNH2 | |
| SCHEMBL7242439 | 0.70 | LMNA (0.43) | SLC6A4SLC6A2SLC6A3LMNAKCNH2 | |
| SCHEMBL9785728 | 0.70 | QPCT (0.52) | SLC6A4SLC6A2SLC6A3TACR1 | |
| Hydrochloric Acid SCHEMBL7250522 | 0.70 | LMNA (0.42) | SLC6A4SLC6A2SLC6A3LMNAKCNH2 | |
| SCHEMBL10771978 | 0.69 | MAPK1 (0.42) | SLC6A4SLC6A2OPRK1 | |
| SCHEMBL7096956 | 0.67 | CHRM2 (0.41) | SLC6A4SLC6A2SLC6A3TACR1OPRD1 | |
| SCHEMBL14370158 | 0.67 | LMNA (0.51) | SLC6A4SLC6A2SLC6A3LMNAKCNH2 | |
| SCHEMBL11779197 | 0.67 | TRPM8 (0.50) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311502-A1 | BICYCLIC HETEROAROMATIC DERIVATIVES FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS | Celltech R&D Limited (GB) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002016353-A1 | BICYCLIC HETEROAROMATIC DERIVATIVES FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS | CELLTECH R & D LIMITED (GB) | 2002-02-28 | — | — | WO | disclosed |