Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199833 | 0.83 | PARP1 (0.66) | PARP1KCNH2GRM2HTR3A | |
| SCHEMBL8824023 | 0.80 | PARP1 (0.68) | PARP1KCNH2GRM2HTR3A | |
| SCHEMBL423080 | 0.75 | PARP1 (0.56) | PARP1KCNH2GRM2HTR3A | |
| SCHEMBL6139222 | 0.73 | PARP1 (0.44) | PARP1KCNH2GRM2HTR3A | |
| SCHEMBL7265263 | 0.72 | PARP1 (0.41) | PARP1KCNH2GRM2HTR3A | |
| Ethylene SCHEMBL6511634 | 0.70 | PARP1 (0.42) | PARP1KCNH2GRM2HTR3A | |
| SCHEMBL7260381 | 0.70 | NPC1 (0.46) | PARP1HTR3A | |
| SCHEMBL7265103 | 0.70 | NPC1 (0.46) | PARP1HTR3A | |
| SCHEMBL9675375 | 0.69 | PARP1 (0.45) | PARP1KCNH2GRM2HTR3A | |
| SCHEMBL7266288 | 0.69 | NPC1 (0.47) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051879-A1 | KNOWN AND NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES USEFUL AS POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2003-06-26 | — | — | WO | disclosed |