Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265103 | 1.00 | NPC1 (0.46) | NPC1SMN1; SMN2RAB9AHPGDTSHR | |
| SCHEMBL7260372 | 0.84 | MAPK14 (0.45) | HDAC4PARP1 | |
| SCHEMBL7266685 | 0.81 | NPSR1 (0.49) | HPGDALDH1A1CYP1A2HDAC4JAK1 | |
| SCHEMBL7266288 | 0.80 | NPC1 (0.47) | NPC1SMN1; SMN2RAB9AHPGDTP53 | |
| SCHEMBL7266284 | 0.79 | PARP1 (0.44) | TP53PARP1HTR3A | |
| SCHEMBL7266651 | 0.79 | AKT1 (0.51) | HDAC4PARP1KMT2A | |
| SCHEMBL7261085 | 0.79 | MMP13 (0.49) | NPC1SMN1; SMN2RAB9AMAPK1ALDH1A1 | |
| SCHEMBL6199833 | 0.77 | PARP1 (0.66) | PARP1HTR3A | |
| SCHEMBL8824023 | 0.77 | PARP1 (0.68) | PARP1HTR3A | |
| SCHEMBL7261120 | 0.76 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1GAAPARP1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | disclosed |