Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266685 | 0.85 | NPSR1 (0.49) | ALDH1A1KDM4EHDAC4HDAC6HPGD | |
| SCHEMBL7260372 | 0.84 | MAPK14 (0.45) | PARP1HDAC4HDAC6 | |
| SCHEMBL7266284 | 0.83 | PARP1 (0.44) | TP53PARP1 | |
| SCHEMBL7261724 | 0.83 | CD274 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7261085 | 0.83 | MMP13 (0.49) | NPC1RAB9ASMN1; SMN2LMNAPARP1 | |
| SCHEMBL7261120 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2LMNAPARP1ALDH1A1KDM4E | |
| SCHEMBL7265103 | 0.80 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53PARP1 | |
| SCHEMBL7260381 | 0.80 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53PARP1 | |
| SCHEMBL6199833 | 0.76 | PARP1 (0.66) | PARP1 | |
| SCHEMBL7260415 | 0.75 | ROCK1 (0.43) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | disclosed |