Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.42 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17378062 | 0.90 | KDM4E (0.54) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL900182 | 0.90 | KDM4E (0.54) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL900178 | 0.90 | KDM4E (0.54) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Hydrochloric Acid SCHEMBL16993797 | 0.88 | KDM4E (0.52) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4993895 | 0.87 | KDM4E (0.44) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Ethylene SCHEMBL28132201 | 0.86 | KDM4E (0.50) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL20259387 | 0.85 | KDM4E (0.45) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL1939497 | 0.84 | TGFBR1 (0.42) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL145047 | 0.84 | GGT1 (0.44) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL3137754 | 0.84 | MAPT (0.48) | KDM4EMAPTTHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366064-A1 | TUMOUR TARGETING PRODRUGS ACTIVATED BY METALLO MATRIXPROTEINASES | The Court of Napier University (GB) | 2003-12-03 | — | — | EP | claimed |
| WO-2002072620-A1 | TUMOUR TARGETING PRODRUGS ACTIVATED BY METALLO MATRIXPROTEINASES | THE COURT OF NAPIER UNIVERSITY (GB) | 2002-09-19 | — | — | WO | claimed |
| WO-2015097041-A1 | DYNAMIC MOLECULES AND DYNAMIC COMBINATORIAL LIBRARY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) | 2015-07-02 | — | — | WO | disclosed |
| EP-2886550-A1 | Dynamic molecules and dynamic combinatorial library | Centre National de la Recherche Scientifique (C.N.R.S.) (FR) | 2015-06-24 | — | — | EP | disclosed |
| EP-1366064-A1 | TUMOUR TARGETING PRODRUGS ACTIVATED BY METALLO MATRIXPROTEINASES | The Court of Napier University (GB) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002072620-A1 | TUMOUR TARGETING PRODRUGS ACTIVATED BY METALLO MATRIXPROTEINASES | THE COURT OF NAPIER UNIVERSITY (GB) | 2002-09-19 | — | — | WO | disclosed |