Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.87 |
| ▸ | MAPT | P10636 | 5/20 | 0.87 |
| ▸ | NPC1 | O15118 | 4/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.87 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.68 |
| ▸ | RELA | Q04206 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17279790 | 0.94 | RAB9A (0.77) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL1181434 | 0.93 | RAB9A (1.00) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL17279913 | 0.90 | RAB9A (0.81) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL22307585 | 0.90 | RAB9A (0.81) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL9976035 | 0.88 | RAB9A (0.68) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL1181118 | 0.88 | RAB9A (0.77) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL1181309 | 0.88 | RAB9A (0.77) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL10358672 | 0.87 | RAB9A (0.66) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL17279873 | 0.87 | RAB9A (0.66) | RAB9AMAPTNPC1MAPK1POLB | |
| SCHEMBL14997979 | 0.87 | RAB9A (0.87) | RAB9AMAPTNPC1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141866-A1 | PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-03 | — | — | WO | disclosed |
| US-9867879-B2 | Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO) | VANDERBILT UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | VANDERBILT UNIVERSITY | 2016-07-28 | — | — | US | disclosed |
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | PPOX, HCCS, HMOX2 | RAB9A 1246/4885MAPT 4774/4885NPC1 4229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.