Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 8/20 | 0.44 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329820 | 0.95 | HTR4 (0.47) | HTR4CACNA1IKCNH2NR4A2 | |
| SCHEMBL6327375 | 0.94 | HTR4 (0.47) | HTR4CACNA1IKCNH2 | |
| SCHEMBL7258023 | 0.86 | HTR4 (0.47) | HTR4NR4A2 | |
| SCHEMBL7254333 | 0.86 | HTR4 (0.47) | HTR4NR4A2 | |
| SCHEMBL7257589 | 0.85 | HTR4 (0.49) | HTR4 | |
| SCHEMBL14258189 | 0.85 | NR4A2 (0.53) | HTR4NR4A2 | |
| SCHEMBL7259539 | 0.84 | HTR4 (0.51) | HTR4 | |
| Hydrochloric Acid SCHEMBL6326593 | 0.84 | NR4A2 (0.52) | HTR4NR4A2 | |
| SCHEMBL7259053 | 0.84 | HTR4 (0.46) | HTR4CACNA1IKCNH2NR4A2 | |
| SCHEMBL7254116 | 0.84 | HTR4 (0.44) | HTR4CACNA1IKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |