Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528140 | 0.87 | HDAC4 (0.41) | GABRA1GABRB2TSHRIDO1TDO2 | |
| SCHEMBL8549265 | 0.85 | GABRA1 (0.38) | GABRA1GABRB2TSHRTRIM24TRIM33 | |
| SCHEMBL8377 | 0.80 | GABRA1 (0.43) | GABRA1GABRB2TSHRTRIM24TRIM33 | |
| SCHEMBL1515719 | 0.77 | IDO1 (0.46) | NR1I2TRPM8IDO1TDO2CNR2 | |
| SCHEMBL15528026 | 0.75 | MAOB (0.40) | IDO1TDO2CNR2CES2CES1 | |
| SCHEMBL26999354 | 0.75 | UGT2B7 (0.43) | GABRA1GABRB2TSHR | |
| SCHEMBL5317299 | 0.75 | MAPKAPK2 (0.40) | GABRA1GABRB2TSHRTRIM24TRIM33 | |
| SCHEMBL14125895 | 0.75 | GABRA1 (0.42) | GABRA1GABRB2TSHRTRIM24TRIM33 | |
| SCHEMBL6631529 | 0.75 | GABRA1 (0.38) | GABRA1GABRB2TSHRTRIM24TRIM33 | |
| SCHEMBL26999259 | 0.75 | TSHR (0.39) | GABRA1GABRB2NR1I2TSHRTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956443-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | Buck Institute For Research On Aging (US) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014127042-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2003080553-A1 | CYCLOPENTENE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-10-02 | — | — | WO | disclosed |