SCHEMBL8377

SCHEMBL8377

O=CC(c1ccccc1)c1ccccc1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.43
GABRB2 P47870 1/20 0.43
HPGD P15428 6/20 0.41
CYP2D6 P10635 1/20 0.40
TSHR P16473 1/20 0.39
TRIM24 O15164 1/20 0.39
TRIM33 Q9UPN9 1/20 0.39
MEN1 O00255 1/20 0.37
GAA P10253 1/20 0.37
KMT2A Q03164 1/20 0.37
MMP2 P08253 1/20 0.37
DBH P09172 1/20 0.37
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
POLB P06746 2/20 0.36
SRC P12931 1/20 0.35
LMNA P02545 5/20 0.35
ALOX15 P16050 2/20 0.35
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26999257 0.89 ACP3 (0.41) GABRA1GABRB2HPGDTSHRALDH1A1
SCHEMBL6277081 0.87 ERN1 (0.41) GABRA1GABRB2HPGDCYP2D6TRIM24
SCHEMBL6631529 0.85 GABRA1 (0.38) GABRA1GABRB2HPGDTSHRTRIM24
SCHEMBL26999259 0.85 TSHR (0.39) GABRA1GABRB2CYP2D6TSHRTRIM24
SCHEMBL14125895 0.85 GABRA1 (0.42) GABRA1GABRB2HPGDTSHRTRIM24
SCHEMBL8549265 0.85 GABRA1 (0.38) GABRA1GABRB2HPGDTSHRTRIM24
SCHEMBL5317299 0.85 MAPKAPK2 (0.40) GABRA1GABRB2HPGDTSHRTRIM24
SCHEMBL11221257 0.84 TRPA1 (0.38) GABRA1GABRB2HPGDCYP2D6TSHR
SCHEMBL4686426 0.82 TYR (0.57) HPGDTSHRMEN1GAAKMT2A
SCHEMBL8907980 0.81 MAPT (0.41) GABRA1GABRB2HPGDTSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3014360-A1 DIGITAL PRINTING APPARATUS AND DIGITAL PRINTING PROCESS Xeikon IP B.V. (NL) 2016-05-04 EP claimed
WO-2014209108-A1 DIGITAL PRINTING APPARATUS AND DIGITAL PRINTING PROCESS XEIKON IP BV (NL) 2014-12-31 WO claimed
JP-8277241-A None JP disclosed
US-11873315-B2 Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) 2024-01-16 US disclosed
EP-2844647-A1 PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2- (1 -HYDROXY- ALKYL) - CHROMEN - 4 - ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS Rhizen Pharmaceuticals S.A. (CH) 2015-03-11 EP disclosed
WO-2013035650-A9 METHOD FOR PRODUCING ALPHA - HYDROXY KETONE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-03-13 WO disclosed
WO-2013164801-A1 PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2- (1 -HYDROXY- ALKYL) - CHROMEN - 4 - ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS RHIZEN PHARMACEUTICALS SA (CH) 2013-11-07 WO disclosed
WO-2013035650-A1 METHOD FOR PRODUCING ALPHA - HYDROXY KETONE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-03-14 WO disclosed
EP-2496567-A2 NOVEL BENZOPYRAN KINASE MODULATORS Rhizen Pharmaceuticals S.A. (CH) 2012-09-12 EP disclosed
WO-2011055215-A2 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2011-05-12 WO disclosed
JP-H08277241-A PRODUCTION OF HYDROXYPHENYLBENZYL KETONES AND CRYSTALLINE TRANSFORMATION NIPPON KAYAKU CO LTD 1996-10-22 JP disclosed
US-4166862-A WEIGHT-GAIN PROMOTERS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1979-09-04 US disclosed
US-3949085-A Anabolic-weight-gain promoting compositions containing isoflavone derivatives and method using same CHINOIN GYOGYSZER-ES VEGYESZETI TERMAKEK GYARA RT (HU) 1976-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11873315-B2 Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts ELANE, PNKP, SERPINB1 GABRA1 1124/4885GABRB2 2338/4885HPGD 456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.