Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450203 | 0.86 | NOTUM (0.58) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL31659703 | 0.84 | NOTUM (0.63) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL22039881 | 0.84 | NOTUM (0.63) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL24309122 | 0.84 | MAP4K4 (0.61) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL29458793 | 0.84 | MAP4K4 (0.61) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL3466581 | 0.79 | LMNA (0.58) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL8282019 | 0.79 | MAP4K4 (0.56) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL22170248 | 0.76 | LMNA (0.58) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL5777042 | 0.76 | MAP4K4 (0.56) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H | |
| SCHEMBL17493756 | 0.76 | GAA (0.58) | NOTUMMAP4K4CYP11B1CYP11B2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003040141-A1 | OXAZOLYL-PHENYL-2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-05-15 | — | — | WO | disclosed |