Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30292019 | 0.86 | LMNA (0.58) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL22170248 | 0.86 | LMNA (0.58) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL12117438 | 0.84 | LMNA (0.63) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL29458793 | 0.84 | MAP4K4 (0.61) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL24309122 | 0.84 | MAP4K4 (0.61) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL8227757 | 0.81 | MAP4K4 (0.54) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL12506711 | 0.79 | LMNA (0.58) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL8282019 | 0.79 | MAP4K4 (0.56) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL7260443 | 0.79 | NOTUM (0.58) | LMNAPKMMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL16419070 | 0.79 | IMPDH2 (0.56) | LMNAPKMMAP4K4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031686-A1 | PHENYL-OXAZOLYL DERIVATIVES, PREPARATION METHOD THEREOF, AND RELATED APPLICATION OF THE PHENYL-OXAZOLYL DERIVATIVES AS AN IMPDH INHIBITOR | INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2015-01-29 | — | — | US | disclosed |
| CN-103304555-A | Group of benzene-oxazolyl derivatives and preparation method as well as relevant application thereof as IMPDH (Inosine Monophosphate Dehydrogenase) inhibitor | INST MEDICINAL BIOTECHNOLOGY | 2013-09-18 | — | — | CN | disclosed |
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031686-A1 | PHENYL-OXAZOLYL DERIVATIVES, PREPARATION METHOD THEREOF, AND RELATED APPLICATION OF THE PHENYL-OXAZOLYL DERIVATIVES AS AN IMPDH INHIBITOR | IMPDH1, IMPDH2, IMPA1 | LMNA 2857/4885PKM 212/4885MAP4K4 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.