Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22925561 | 0.84 | NOTUM (0.58) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL24309122 | 0.84 | MAP4K4 (0.61) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL29458793 | 0.84 | MAP4K4 (0.61) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL29620988 | 0.84 | NOTUM (0.58) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL29454499 | 0.84 | BACE1 (0.53) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL8229641 | 0.79 | GAA (0.58) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL3466581 | 0.79 | LMNA (0.58) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL8418297 | 0.79 | LMNA (0.58) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL14561709 | 0.79 | NOTUM (0.53) | MAP4K4NOTUMCYP11B1CYP11B2LMNA | |
| SCHEMBL7260443 | 0.79 | NOTUM (0.58) | MAP4K4NOTUMCYP11B1CYP11B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745047-B1 | PYRAZOLO[4,3-E]-1,2,4-TRIAZOLO[1,5-C]PYRIMIDINE ADENOSINE-A2A- RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |