Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990959 | 0.87 | EGFR (0.38) | EGFRCSNK2A1CSNK2A2CSNK2BCYP3A4 | |
| SCHEMBL5147804 | 0.81 | EGFR (0.38) | EGFRKDRCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL5147750 | 0.79 | RAB9A (0.37) | MAPTTP53RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7260715 | 0.78 | EGFR (0.39) | MAPTTP53RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7610217 | 0.77 | LMNA (0.50) | MAPTRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL7260724 | 0.76 | EGFR (0.39) | MAPTTP53RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5224258 | 0.75 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2NPC1HPGDL3MBTL1 | |
| SCHEMBL3833596 | 0.73 | MEN1 (0.32) | RAB9ASMN1; SMN2NPC1L3MBTL1MEN1 | |
| SCHEMBL6131672 | 0.73 | ITGB1 (0.38) | CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3832798 | 0.73 | ITGB1 (0.38) | CSNK2A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370531-A1 | PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS | Celltech R & D Limited (GB) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002068393-A1 | PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-09-06 | — | — | WO | disclosed |