Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.42 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18896189 | 0.97 | KCNA3 (0.47) | KCNA3ALOX5HPGDANO1CTSL | |
| SCHEMBL883600 | 0.84 | HPGD (0.56) | HPGDCTSLALDH1A1LMNAMAPT | |
| Methylamine SCHEMBL7258774 | 0.82 | SMN1; SMN2 (0.51) | HPGDANO1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL18896227 | 0.82 | ALDH1A1 (0.52) | HPGDANO1CTSLALDH1A1SMN1; SMN2 | |
| SCHEMBL13663588 | 0.81 | ALOX5 (0.69) | KCNA3ALOX5HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7137660 | 0.80 | CES2 (0.55) | KCNA3ALOX5ANO1ALDH1A1GAA | |
| SCHEMBL27409724 | 0.80 | ALDH1A1 (0.61) | KCNA3HPGDALDH1A1SMN1; SMN2GAA | |
| SCHEMBL13886794 | 0.79 | ITGB1 (0.47) | KCNA3ALOX5HPGDANO1ALDH1A1 | |
| SCHEMBL30591460 | 0.79 | ALOX5 (0.66) | ALOX5HPGDANO1ALDH1A1KDM4E | |
| SCHEMBL1829008 | 0.79 | CYP4F2 (0.41) | ANO1CTSLALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003077857-A2 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |