Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.83 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.83 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.83 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.83 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.83 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL25895 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL140812 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL9120917 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL8110265 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Alpha-Hexachlorocyclohexane SCHEMBL140813 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| SCHEMBL8406626 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL472088 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL75689 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10795898 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL9242537 | 0.91 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1314186-A2 | SAMPLE INTRODUCTION INTERFACE FOR ANALYTICAL PROCESSING | Newton Scientific, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002016927-A2 | SAMPLE INTRODUCTION INTERFACE FOR ANALYTICAL PROCESSING | NEWTON SCIENTIFIC, INC. (US) | 2002-02-28 | — | — | WO | disclosed |
| US-4919858-A | MIXTURE OF PARTICULATE MAGNETIC MATERIAL AND ORGANIC MATERIAL IN A MOLD WHICH IS ROTATED MATERIAL IS CROSSLINKED BY HEAT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-04-24 | — | — | US | disclosed |
| EP-0318252-A2 | Process for the production of a bonded magnet | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |
| EP-0318251-A2 | Compositions for the production of magnets and magnets produced therefrom | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |