Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.65 |
| ▸ | CDK2 | P24941 | 5/20 | 0.65 |
| ▸ | CDK1 | P06493 | 4/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.65 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.50 |
| ▸ | AHCY | P23526 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268668 | 1.00 | ADORA2A (0.67) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL7263234 | 1.00 | ADORA2A (0.67) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| Alcohol SCHEMBL7263252 | 0.96 | CCNE1 (0.64) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL17194158 | 0.85 | ADORA2A (0.56) | ADORA2AADORA1CCNE1CDK2HSP90AA1 | |
| SCHEMBL23867114 | 0.84 | CCNE1 (0.68) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL23710566 | 0.84 | AHCY (0.68) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL16131314 | 0.82 | CCNE1 (0.57) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL2552058 | 0.82 | CCNE1 (0.57) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL2552941 | 0.82 | CCNE1 (0.57) | ADORA2AADORA1CCNE1CDK2CDK1 | |
| SCHEMBL7749494 | 0.82 | CCNE1 (0.65) | ADORA2AADORA1CCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653296-B1 | 2-phosphonomethoxypropyl derivatives of purine and pyrimidine bases | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2003-11-25 | — | — | US | disclosed |
| US-6479673-B1 | Antiretroviral enantiomeric nucleotide analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2002-11-12 | — | — | US | disclosed |
| US-6057305-A | Antiretroviral enantiomeric nucleotide analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2000-05-02 | — | — | US | disclosed |
| EP-0654037-B1 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1999-05-12 | — | — | EP | disclosed |
| EP-0654037-A1 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003467-A2 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1994-02-17 | — | — | WO | disclosed |