Alcohol

Alcohol

SCHEMBL7263252

CCO.C[C@@H](O)Cn1cnc2c(N)nc(N)nc21

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CCNE1 P24864 5/20 0.64
CDK2 P24941 5/20 0.64
CDK1 P06493 4/20 0.64
CCNB1 P14635 4/20 0.64
ADORA2A P29274 3/20 0.62
ADORA1 P30542 2/20 0.62
SLC29A1 Q99808 1/20 0.50
AHCY P23526 3/20 0.47
HSP90AA1 P07900 1/20 0.43
HSP90AB1 P08238 1/20 0.43
ALDH1A1 P00352 1/20 0.42
CYP1A2 P05177 1/20 0.41
PI4KA P42356 1/20 0.40
PI4K2B Q8TCG2 1/20 0.40
PI4K2A Q9BTU6 1/20 0.40
PI4KB Q9UBF8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7263232 0.96 ADORA2A (0.67) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL7268668 0.96 ADORA2A (0.67) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL7263234 0.96 ADORA2A (0.67) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL23710566 0.83 AHCY (0.68) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL23867114 0.83 CCNE1 (0.68) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL17194158 0.82 ADORA2A (0.56) CCNE1CDK2ADORA2AADORA1HSP90AA1
SCHEMBL7749494 0.81 CCNE1 (0.65) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL24829634 0.79 CCNE1 (0.55) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL2554652 0.79 CCNE1 (0.58) CCNE1CDK2CDK1CCNB1ADORA2A
SCHEMBL8767031 0.79 CCNE1 (1.00) CCNE1CDK2CDK1CCNB1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6653296-B1 2-phosphonomethoxypropyl derivatives of purine and pyrimidine bases INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2003-11-25 US disclosed
US-6479673-B1 Antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2002-11-12 US disclosed
US-6057305-A Antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2000-05-02 US disclosed
EP-0654037-B1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1999-05-12 EP disclosed
EP-0654037-A1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1995-05-24 EP disclosed
WO-1994003467-A2 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1994-02-17 WO disclosed