Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | FAP | Q12884 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176435 | 1.00 | CYP3A4 (0.49) | CYP3A4FAPHSP90AB1HSP90AA1HDAC1 | |
| SCHEMBL9177023 | 1.00 | CYP3A4 (0.49) | CYP3A4FAPHSP90AB1HSP90AA1HDAC1 | |
| SCHEMBL14244311 | 0.89 | CYP3A4 (0.47) | CYP3A4FAPHSP90AB1HSP90AA1HDAC1 | |
| SCHEMBL23223510 | 0.88 | FAP (0.48) | CYP3A4FAPHSP90AB1HSP90AA1HDAC1 | |
| SCHEMBL17194161 | 0.88 | FAP (0.48) | CYP3A4FAPHSP90AB1HSP90AA1HDAC1 | |
| SCHEMBL13360654 | 0.88 | HSP90AB1 (0.44) | CYP3A4HSP90AB1HSP90AA1HDAC1HDAC6 | |
| SCHEMBL8752233 | 0.87 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1HDAC1HDAC6HDAC4 | |
| SCHEMBL8752184 | 0.87 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1HDAC1HDAC6HDAC4 | |
| SCHEMBL6902158 | 0.87 | CYP3A4 (0.65) | CYP3A4HSP90AB1HSP90AA1HDAC1HDAC6 | |
| SCHEMBL6902140 | 0.87 | CYP3A4 (0.65) | CYP3A4HSP90AB1HSP90AA1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653296-B1 | 2-phosphonomethoxypropyl derivatives of purine and pyrimidine bases | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2003-11-25 | — | — | US | disclosed |
| US-6479673-B1 | Antiretroviral enantiomeric nucleotide analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2002-11-12 | — | — | US | disclosed |
| US-6057305-A | Antiretroviral enantiomeric nucleotide analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2000-05-02 | — | — | US | disclosed |
| EP-0654037-B1 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1999-05-12 | — | — | EP | disclosed |
| EP-0452935-B1 | Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1995-06-21 | — | — | EP | disclosed |
| EP-0654037-A1 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1995-05-24 | — | — | EP | disclosed |
| US-5302585-A | Viricides, HIV virus | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1994-04-12 | — | — | US | disclosed |
| WO-1994003467-A2 | ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1994-02-17 | — | — | WO | disclosed |
| EP-0452935-A1 | Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1991-10-23 | — | — | EP | disclosed |