Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267860 | 0.81 | MEN1 (0.65) | PDE5AMEN1KMT2AABCG2ALDH1A1 | |
| SCHEMBL7269225 | 0.79 | ABCG2 (0.45) | PDE5ANPY5RMEN1KMT2AABCG2 | |
| SCHEMBL7269218 | 0.79 | ABCG2 (0.45) | PDE5ANPY5RMEN1KMT2AABCG2 | |
| SCHEMBL7262716 | 0.79 | MEN1 (0.48) | PDE5AMEN1KMT2AABCG2LMNA | |
| SCHEMBL10135256 | 0.78 | NPY5R (0.67) | PDE5ANPY5RMEN1KMT2AABCG2 | |
| SCHEMBL7270105 | 0.76 | PDE5A (0.47) | PDE5AMEN1KMT2AABCG2LMNA | |
| SCHEMBL7262166 | 0.74 | MAOA (0.45) | PDE5AMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL13903883 | 0.73 | MEN1 (0.69) | PDE5ANPY5RMEN1KMT2AABCG2 | |
| SCHEMBL6714548 | 0.72 | KDM1A (0.66) | MEN1KMT2ACYP1A2LMNACYP2D6 | |
| SCHEMBL7434073 | 0.72 | PDE5A (1.00) | PDE5ANPY5RMEN1KMT2AABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656949-B1 | Ability to inhibit the growth of a variety of tumor/cancer cells (particularly melanoma cell lines UACC-62 and UACC-257, and one of the renal cancer cell lines, i.e. UO-31) | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2003-12-02 | — | — | US | disclosed |
| US-6656949-B1 | Ability to inhibit the growth of a variety of tumor/cancer cells (particularly melanoma cell lines UACC-62 and UACC-257, and one of the renal cancer cell lines, i.e. UO-31) | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2003-12-02 | — | — | US | disclosed |