Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 2/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 3/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
| ▸ | NMUR2 | Q9GZQ4 | 2/20 | 0.36 |
| ▸ | NMUR1 | Q9HB89 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7264433 | 1.00 | EPHA2 (0.38) | EPHA2BDKRB2ERAP2ERAP1LNPEP | |
| SCHEMBL7263930 | 0.93 | DPP4 (0.41) | EPHA2BDKRB2ERAP2ERAP1LNPEP | |
| Arginine SCHEMBL7263659 | 0.93 | DPP8 (0.40) | EPHA2BDKRB2ERAP2ERAP1LNPEP | |
| Arginine SCHEMBL7264249 | 0.91 | BDKRB2 (0.38) | EPHA2BDKRB2ERAP2ERAP1LNPEP | |
| Arginine SCHEMBL7270470 | 0.91 | DPP4 (0.38) | EPHA2BDKRB2ACEDPP4DPP8 | |
| Arginine SCHEMBL7265631 | 0.89 | PLK1 (0.34) | EPHA2BDKRB2NMUR2NMUR1 | |
| Lysine SCHEMBL7265717 | 0.88 | ACE (0.43) | ERAP2ERAP1LNPEPACEDPP8 | |
| SCHEMBL7265481 | 0.86 | ERAP2 (0.42) | ERAP2ERAP1LNPEPACE | |
| Ammonia Solution, Strong SCHEMBL10829251 | 0.86 | ERAP2 (0.42) | ERAP2ERAP1LNPEPACE | |
| Arginine SCHEMBL10866107 | 0.84 | DPP4 (0.37) | EPHA2BDKRB2ACENMUR2NMUR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60028991-A | — | — | None | — | — | JP | disclosed |
| JP-59031788-A | — | — | None | — | — | JP | disclosed |
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| JP-S6028991-A | AMINO ACID DERIVATIVE AND HYPOTENSIVE AGENT CONTAINING THE SAME | AJINOMOTO CO INC | 1985-02-14 | — | — | JP | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| JP-S5931788-A | AMINO ACID DERIVATIVE AND HYPOTENSOR CONTAINING THE SAME | AJINOMOTO CO INC | 1984-02-20 | — | — | JP | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |