Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.32 |
| ▸ | NMUR2 | Q9GZQ4 | 4/20 | 0.31 |
| ▸ | NMUR1 | Q9HB89 | 4/20 | 0.31 |
| ▸ | RAMP3 | O60896 | 3/20 | 0.31 |
| ▸ | CALCR | P30988 | 3/20 | 0.31 |
| ▸ | OTC | P00480 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7264280 | 0.92 | DPP8 (0.37) | — | |
| Arginine SCHEMBL7264433 | 0.89 | EPHA2 (0.38) | EPHA2BDKRB2NMUR2NMUR1 | |
| Arginine SCHEMBL7263652 | 0.89 | EPHA2 (0.38) | EPHA2BDKRB2NMUR2NMUR1 | |
| SCHEMBL7271634 | 0.85 | ACE (0.40) | XIAP | |
| Arginine SCHEMBL7263659 | 0.83 | DPP8 (0.40) | EPHA2BDKRB2NTSR2NTSR1SORT1 | |
| SCHEMBL7263930 | 0.81 | DPP4 (0.41) | EPHA2BDKRB2 | |
| Arginine SCHEMBL7264249 | 0.80 | BDKRB2 (0.38) | EPHA2BDKRB2 | |
| Arginine SCHEMBL7270470 | 0.79 | DPP4 (0.38) | PLK1EPHA2BDKRB2 | |
| SCHEMBL7270446 | 0.79 | DPP8 (0.46) | — | |
| Arginine SCHEMBL10866107 | 0.78 | DPP4 (0.37) | EPHA2BDKRB2NMUR2NMUR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |