Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7264433 | 0.91 | EPHA2 (0.38) | DPP4BDKRB2ACEDPP8DPP7 | |
| Arginine SCHEMBL7263652 | 0.91 | EPHA2 (0.38) | DPP4BDKRB2ACEDPP8DPP7 | |
| SCHEMBL7263930 | 0.90 | DPP4 (0.41) | DPP4BDKRB2DPP8DPP7DPP9 | |
| Arginine SCHEMBL7264249 | 0.88 | BDKRB2 (0.38) | DPP4BDKRB2ACEDPP8DPP7 | |
| Arginine SCHEMBL7263659 | 0.88 | DPP8 (0.40) | BDKRB2ACEDPP8EPHA2 | |
| Lysine SCHEMBL7265717 | 0.80 | ACE (0.43) | ACEDPP8F2 | |
| Arginine SCHEMBL7265631 | 0.79 | PLK1 (0.34) | BDKRB2EPHA2PLK1 | |
| Arginine SCHEMBL7264280 | 0.79 | DPP8 (0.37) | DPP4DPP8DPP7DPP9 | |
| Arginine SCHEMBL7270466 | 0.77 | ACE (0.42) | DPP4ACE | |
| SCHEMBL7263653 | 0.76 | DPP4 (0.50) | DPP4ACEDPP8DPP7DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |