Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210468 | 0.74 | RAB9A (0.51) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL5694141 | 0.73 | DYRK1A (0.47) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL3627806 | 0.71 | DCK (0.43) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL5344718 | 0.71 | RAB9A (0.41) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL10348673 | 0.70 | MAPK14 (0.44) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL8303938 | 0.68 | ABCB1 (0.40) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL27622346 | 0.67 | RAB9A (0.37) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL15474750 | 0.67 | RAB9A (0.50) | RAB9ATSHRL3MBTL1KMT2ANPC1 | |
| SCHEMBL10348640 | 0.67 | RAB9A (0.46) | RAB9ATSHRL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL10335889 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649750-B1 | Nucleoside linked to a support through heterocyclic base and amide bond; deblocking/deprotecting; capping/oxidizing; purity; reduced levels of byproducts containing abasic sites | ISIS PHARMACEUTICALS, INC. | 2003-11-18 | — | — | US | claimed |