Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000811 | 0.89 | CACNA1C (0.54) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL7273125 | 0.85 | LMNA (0.47) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL7272913 | 0.84 | KMT2A (0.46) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL7273136 | 0.82 | ALDH1A1 (0.41) | KMT2AMAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11576496 | 0.78 | CACNA1D (0.52) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL11167378 | 0.78 | CACNA1D (0.52) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL10866129 | 0.76 | KMT2A (0.45) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL10864205 | 0.76 | ALDH1A1 (0.34) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL11346454 | 0.75 | CACNA1D (0.55) | LMNACACNA1CKMT2AADORA3CYP1A2 | |
| SCHEMBL10528018 | 0.75 | CACNA1D (0.55) | LMNACACNA1CKMT2AADORA3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |