Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665253 | 0.83 | LMNA (0.86) | PKMLMNATSHRPIK3CAALDH1A1 | |
| SCHEMBL12499681 | 0.79 | PIK3CA (0.73) | PKMLMNATSHRPIK3CAALDH1A1 | |
| SCHEMBL15613182 | 0.77 | LMNA (1.00) | PKMLMNATSHRALDH1A1NPSR1 | |
| SCHEMBL16872910 | 0.76 | PKM (0.71) | PKMLMNATSHRALDH1A1NPSR1 | |
| SCHEMBL6742541 | 0.74 | MTOR (0.73) | LMNATSHRPIK3CAALDH1A1NPSR1 | |
| SCHEMBL1443593 | 0.72 | PIK3CA (0.61) | PKMLMNAPIK3CAALDH1A1PIK3R1 | |
| SCHEMBL1396153 | 0.72 | PKM (0.58) | PKMPIK3CAALDH1A1PIK3R1MTOR | |
| SCHEMBL11900640 | 0.72 | TSHR (0.80) | PKMLMNATSHRALDH1A1NPSR1 | |
| SCHEMBL17767825 | 0.71 | PKM (0.62) | PKMLMNATSHRPIK3CAALDH1A1 | |
| SCHEMBL14128251 | 0.70 | LMNA (0.83) | PKMLMNAPIK3CAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004000820-A2 | CERTAIN AROMATIC MONOCYCLES AS KINASE MODULATORS | CELLULAR GENOMICS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |