Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264444 | 0.90 | KMT2A (0.42) | CACNA1FCACNA1DCACNA1SCACNA1CHPGD | |
| SCHEMBL7263749 | 0.88 | CACNA1B (0.38) | KMT2AMAPT | |
| SCHEMBL10995695 | 0.84 | CACNA1F (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 | |
| SCHEMBL7265676 | 0.84 | ALDH1A1 (0.38) | CACNA1CHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7271831 | 0.83 | GAA (0.38) | HPGDKDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL7263816 | 0.83 | CYP2C9 (0.45) | CACNA1FCACNA1DCACNA1SCACNA1CHPGD | |
| SCHEMBL10786550 | 0.81 | CACNA1F (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 | |
| SCHEMBL7264423 | 0.80 | MEN1 (0.48) | CACNA1FCACNA1DCACNA1SCACNA1CGAA | |
| SCHEMBL7265694 | 0.79 | CACNA1B (0.41) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL8437311 | 0.78 | CACNA1F (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |