Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264445 | 0.90 | CACNA1F (0.41) | KMT2ACACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7271831 | 0.89 | GAA (0.38) | KMT2AMAPTGAAALDH1A1MEN1 | |
| SCHEMBL7263749 | 0.88 | CACNA1B (0.38) | KMT2AMAPTTP53 | |
| SCHEMBL7265676 | 0.86 | ALDH1A1 (0.38) | KMT2AADORA3CACNA1CADORA2AADORA1 | |
| SCHEMBL7264423 | 0.85 | MEN1 (0.48) | KMT2AADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL10995365 | 0.84 | ADORA3 (0.55) | KMT2AADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7263816 | 0.83 | CYP2C9 (0.45) | KMT2AADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7265665 | 0.83 | MAPT (0.51) | KMT2AADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL10367338 | 0.82 | ADORA3 (0.34) | KMT2AADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL10786897 | 0.80 | ADORA3 (0.52) | KMT2AADORA3CACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |